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Welcome in the web page of Dr. Basem Kanawati
Scientific Track
 
[Nov.2007-To date] Mass Spectrometry Scientist in the research unit: Analytical BioGeoChemistry in Helmholtz Center Munich - 12Tesla FT-ICR-MS laboratory.
 
  Organic Mass Spectrometry with emphasis of pesticides and herbicides environmental and catalytic biodegradation.
 
  Physical simulation of ion trajectories inside ion traps and ICR cells.
 
  Data Processing of FTMS frequency and mass spectra.
 
  Automation and advanced system control of FTMS acquisitions for increasing productivity in FTMS labs.
 
  Elucidation of advanced fragmentation mechanisms of ionic systems as well as ion-neutral recombination mechanisms by quantum mechanical DFT investigations and mass spectrometric collision induced dissociation experiments.
 
  Transition state engineering for several gas phase rearrangements of ionic and neutral systems and study of isodesmic reactions. Calculations of electronic properties of molecular structures.
 
[Dec.2005- Nov.2007] Postdoc in Max-Planck Institute for atmospheric chemistry:
 
  “Mass spectrometric investigations of organic aerosols using different external ionisation sources in Triple-Quadrupole-TOF LC-MS/MS hybrid system”.
 
 “Elucidation of gas phase fragmentation mechanisms for closed shell anions of different oxocarboxylic acids by use of collision induced dissociation experiments and DFT quantum mechanical calculations”.
 
[2004- Dec.2005] Scholarship holder of VCI (Verband der Chemischen Industrie) & PhD. in gas phase chemistry ICR mass spectrometry in the University of Bremen/Germany under the supervision of Prof. Dr. Karl-Peter Wanczek.
 
“Gas Phase Negative Ion Chemistry of Tris(trifluoromethyl)phosphine and Characterization of Cylindrical Open ICR cell with electrodes of different diameters”.
 
[End of 2003] Diplom Degree in Chemistry (Total Grade = 1) in the University of Bremen.
 
[2001-2005] Seminar and Lab Tutor for the course “Chemistry for Physicists” in the University of Bremen.
 
[2003-2005] Seminar and Lab Tutor for the course “Micro qualitative Analysis for Chemists” in the University of Bremen.
 
[2000-2001] German Studies with DSH certificates from the University of Freiburg and the University of Bremen.
 
[1997-1999] Computer Teacher in Bayan Co. Computer Institute for the course: “Advanced Excel and Access Programming” in Damascus.
 
[1992-1996] Bachelor Degree of Science (Total grade : Very good) from the University of Damascus.

 

Computer Skills

• Visual Basic for Excel Programming. Computer Skills:

 • MATLAB (Advanced Math Program). I designed new programs for laboratorial system control and automation - coupling of mass spectrometer with auto samplers by the use of microcontrollers.

• Gaussian for quantum mechanical calculations of chemical structures (energy barrier heights for isodesmic chemical reactions, electron affinities, proton affinities, optimized geometries, NMR chemical shifts, NCIS magnetic shields).

 • SIMION for ion trajectory calculations for design inventions. Simulation of ions under combined electrical and magnetic fields. I discovered new types of ion motion in novel electrical devices. • Autodesk Inventor (Advanced 3D CAD program for construction of metal works).

• Hierarcial Clustering Explorer for data classification and biomarker identification. • Programs for controling several mass spectrometers and performing data analysis (Bruker‘s Data Analysis, MDS Sciex Analyst, Bruker‘s Xmass, Bruker‘s Aspect & Quantra software).

 
Instruments:
 
Bruker’s Apex & Solarix high resolution FT-ICR mass spectrometers with 12T Magnex magnet.
 
QSTAR Triple Quadrupole- Orthogonal acceleration - TOF-MS/MS hybrid system from MDS Sciex.
 
Quantra FT-ICR mass spectrometer for GC-MS analysis.
 
 
Peer reviewed publications:

1. Gas Phase FT ICR Investigation of the Production of Phosphoranides and Ion Chemistry of Tris(trifluoromethyl)phosphine.
B Kanawati, KP Wanczek. International Journal of Mass Spectrometry, (2007): 264/(2-3), 164-174.

2. Characterisation of a New Open Cylindrical ICR Cell with unusual geometry. B Kanawati, KP Wanczek. Review of Scientific Instruments, (2007): 78 (7), 074102.

3. Mass spectrometric characterisation of small oxocarboxylic acids and gas phase ion fragmentation mechanisms studied by Electrospray Triple Quadrupole-MS/MS-TOF system and DFT Theory. B Kanawati, S Joniec, R Winterhalter, GK Moortgat. International Journal of Mass Spectrometry, (2007): 266 (1-3) 97-113.

4. Characterisation of a New Open Cylindrical ICR Cell for Ion-Ion Collision Studies. B Kanawati, KP Wanczek. International Journal of Mass Spectrometry, (2008): 269, (1-2), 12-23.

5. Mass spectrometric characterisation of beta-caryophyllene ozonolysis products in the aerosol studied by Electrospray Triple Quadrupole-MS/MS-TOF system and DFT Theory. B Kanawati, F Herrmann, S Joniec, R Winterhalter , GK Moortgat. Rapid Communications in Mass Spectrometry. (2008): 22 (2), 165-186.

6. Oligomer formation during gas-phase ozonolysis of small alkenes and enol ethers: new evidence for the central role of the Criegee Intermediate as oligomer chain unit. A Sadezky, R Winterhalter, B Kanawati, A Römpp, B Spengler, A Mellouki, G Le Bras, P Chaimbault, GK Moortgat. Atmospheric Chemistry and Physics Discussions (2007): 7, 14041–14102.

7. RF-driven Ion-Ion Long Range Interaction in a New Open Cylindrical ICR cell. B Kanawati, KP Wanczek. International Journal of Mass Spectrometry (2008): 274, (1-3), 30-47.

8. Mass spectrometric characterisation of 4-oxopentanoic acid and gas phase ion fragmentation mechanisms studied by Electrospray Triple Quadrupole-MS/MSTOF system and DFT Theory. B Kanawati, S Joniec, R Winterhalter , GK Moortgat, Rapid Communications in Mass Spectrometry, (2008): 22 (14), 2269-2279.

9. Photocatalytic Reactions of Imazamox at TiO2, H2O2 and TiO2/H2O2 in Water Interfaces: Kinetic and Photoproducts Study. M Harir, A Gaspar, B Kanawati, M Frommberger, A Fekete, D Martens, A Kettrup, M El Azzouzi, P Schmitt-Kopplin J. Appl. Cat. B, (2008): 84 (3-4), 524-532.

10. Exploring Rearrangements along the Fragmentation Pathways of Diuron Anion: A combined experimental and computational investigation B Kanawati, M Harir, P Schmitt-Kopplin International Journal of Mass Spectrometry, (2009): 288 (1-3), 6-15.

11. Automated microextraction sample preparation coupled on-line to FT-ICR-MS: application to desalting and concentration of river and marine dissolved organic matter. G Morales-Cid. , I Gebefügi, B Kanawati, M Harir, P Schmitt-Kopplin, M Valcarcel, BM Simonet, S Cardenas. Analytical Bioanalytical Chemistry, (2009): 395:797–807.

12. The gas-phase ozonolysis of ß-caryophyllene (C15H24). Part I: an experimental study. R Winterhalter, F Herrmann, B Kanawati, TL Nguyen, J Peeters, L Vereeckenb, GK Moortgatat. Physical Chemistry Chemical Physics (2009): 11, 4152–4172.

13. The gas-phase ozonolysis of -caryophyllene (C15H24). Part II: A theoretical Study. TL Nguyen, R Winterhalter, GK Moortgat, B Kanawati, J Peeters, L Vereecken. Physical Chemistry Chemical Physics (2009): 11, 4173 – 4183.

14. Can tetra-tert-butylethylene be formed by ion–ion recombination or ion–molecule reaction of two di-tert-butylcarbene units?—a DFT study B Kanawati, D Lenoir, P Schmitt-Kopplin. Journal of Physical Organic Chemistry. Journal of Physical Organic Chemistry. (2010): 24, 83–91.

15. High molecular diversity of extraterrestrial organic matter in Murchison meteorite revealed 40 years after its fall. P Schmitt-Kopplin , Z Gabelica, R Gougeon, A Fekete, B Kanawati, I Gebefuegi, G Eckel, N Hertkorn. Proceedings of the National Academy of Sciences, (2010): 107 (7), 2763-2768.

16. Exploring rearrangements along the fragmentation of glutaric acid negative ion:A combined experimental and theoretical study. B Kanawati, P Schmitt-Kopplin. Rapid Communications in Mass Spectrometry (2010): 24 (8), 1198 – 1206.

17. Pathway analysis of the transcriptome and metabolome of a salt sensitive and tolerant poplar species reveals evolutionary adaption of stress tolerance mechanisms. D Janz, K Behnke, JP Schnitzler, B Kanawati, P Schmitt-Kopplin, A Polle (2010): BMC Plant Biology, 10, 150.

18. Hydrolysis of Mefenpyrdiethyl: an analytical and DFT investigation A Chnirheb, M Harir, B Kanawati, A Fekete, M El Azzouzi, N Hertkorn, P Schmitt-Kopplin Analytical and Bioanalytical Chemistry (2010): 398(5), 2325-34.

19. Mass spectrometric stereo chemical differentiation between alpha and beta ascorbic acid 2-glycosides: Experimental and DFT study. B Kanawati, VV Saint-Paul, AR Schaefner, P Schmitt-Kopplin. Rapid Communications in Mass Spectrometry, (2011): 25(6):806-14.

20. The Arabidopsis glucosyltransferase UGT76B1 conjugates isoleucic acid and modulates plant defense and senescence VV Saint Paul, B Kanawati, W Zhang, B Geist, T Faus-Keßler, P Schmitt-Kopplin, AR Schäffner (2011): Plant Cells, 23(11): 4124–4145.

21. Novel Cysteine Tags for the Sequencing of Non-Tryptic Disulfide Peptides of Anurans:ESI-MS Study of Fragmentation Efficiency. TY Samgina, EA Vorontsov, VA Gorshkov, KA Artemenko, IE Nifant’ev, B Kanawati,P Schmitt-Kopplin, RA Zubarev, AT Lebedev. American Society for Mass Spectrometry, (2011), 22, 2246-2255.

22. Detection of Peptidic Sequences in the Ancient Acidic Sediments of Río Tinto, Spain. M Colín-García & B Kanawati , M Harir , P Schmitt-Kopplin , R Amils , V Parro , M García , D Fernández-Remolar. Origins of Life and Evolution of Biospheres, (2011), 41(6):523-527.

23. Photocatalytic Efficiency of TiO2 P-25 and Humbikat UV100 against Mefenpyrdiethyl in Water: Kinetics and Degradation Products Study Amina Chnirheb, Mourad Harir, Basem Kanawati, Mohammed El Azzouzi, Istvan Gebefügi, Philippe Schmitt-Kopplin. Journal of Environmental Science (2011).

24. Dissolved organic matter in sea spray: a transfer study from marine surface water to aerosols. Philippe Schmitt-Kopplin, Gérard Liger-Belair, Boris P. Koch, Ruth Flerus, Gerhard Kattner, Mourad Harir, Basem Kanawati, Marianna Lucio, Dimitrios Tziotis, Norbert Hertkorn, Istvan Gebefügi. Biogeosciences Discussions. A journal of the European Geosciences Union (2011). 8, 11767–11793.

25. Analysis of glutathione-S-transferases from Arabidopsis in yeast. Matthias P. Krajewski, Basem Kanawati, Agnes Fekete, Nathalie Kowalski, Phillippe Schmitt-Kopplin, and Erwin Grill. Photochemistry (2012), 91:198-207.

26. Attachment of Chloride Anion to Sugars: Mechanistic Investigation and Discovery of a New Dopant for Efficient Sugar Ionization/Detection in Mass Spectrometers Lemia Boutegrabet, Basem Kanawati, Istvan Gebefügi, Dominique Peyron, Philippe Cayot, Régis D. Gougeon, Philippe Schmitt-Kopplin. Chemistry, A European Journal (2012), 18(41):13059-13067.

27. Bis-dibenzo[a.i]fluorenylidene, does it exist as a stable 1,2-diradical? Basem Kanawati, Alexander Genest, Philippe Schmitt-Kopplin, Dieter Lenoir. Journal of Molecular Modeling (2012). DOI: 10.1007/s00894-012-1502-4.

28. Pre-focusing inside a linear ion beam guide - SIMION study. Basem Kanawati, Karl-Peter Wanczek, Istvan Gebefügi, Philippe Schmitt-Kopplin. International Journal of Mass Spectrometry, Special Issue (2012), 325, 25–29.

29. Atmospheric CO2 determines metabolic differences between isoprene and non-isoprene emitting poplas – low CO2 as a selective trait for the evolution of plant isoprene emission. Danielle A. Way, Andrea Ghirado, Basem Kanawati, Jürgen Esperschütz, Russel K. Munson, Robert B. Jackson, Philippe Schmitt-kopplin, Jörg-Peter Schnitzler. New Phytologist, (2013). doi: 10.1111/nph.12391.

30. Hippocampal metabolomics using ultrahigh resolution mass spectrometry reveals neuroinflammation in the CRND8 mice of Alzheimer’s disease. Shuhai Lin, Hongde Liu, Basem Kanawati, Liangfeng Liu, Jiyang Dong, Min Lid, Jiandong Huang, Philippe Schmitt-Kopplin, Zongwei Cai Accepted, In press - Special Issue in Analytical Bioanalytical Chemistry (2013), 405(15):5105-5117.

31. Two contrasting poplar species show different isoprene emission rates and photosynthetic capacities under combined high salinity and sunflecks Katja Behnke, Andrea Ghirardo, Jürgen Esperschütz, Basem Kanawati, Dennis Janz, Ulö Ninemets, Andrea Polle, Jörg-Peter Schnitzler, Maaria Rosenkranz. Accepted, In Press, Journal of Tree Physiology (2013), doi:10.1093/treephys/tpt018.

32. Manganese speciation in paired serum and CSF samples using SEC- DRC-ICP-MS and CE-DRC-ICP-MS B. Michalke, M. Lucio, B. Kanawati, A. Berthele. Analytical Bioanalytical Chemistry Journal (2013), 405(7):2301-2309.

33. Review on liquid chromatography mass spectrometry techniques in non-targeted metabolomics research: historical aspects and perspectives. Special issue: state-of-the art of (UHP)LC-MS techniques and their practical application Sara Forcisi, Franco Moritz, Basem Kanawati, Dimitrios Tziotis, Philippe Schmitt-Kopplin. Journal of Chromatography A (2013), 1292, 51-65.

34. Integrated transcriptomics and metabolomics decipher differences in the resistence of pedunculate oak to the herbivore Tortrix viridana L. Kersten Birgit, Birgit Kersten, Andrea Ghirardo, Jörg-Peter Schnitzler, Basem Kanawati, Philippe Schmitt-Kopplin, Matthias Fladung, Hilke Schroeder, BMC Genomics. (2013), 14:737.

35. Chromatography and High-Resolution Mass Spectrometry for the Characterization of the Degradation Products of the Photodegradation of Amidosulfuron: An Analytical Approach. Harir, Mourad, Amina Chnirheb, Basem Kanawati, Mohammed El Azzouzi, Philippe Schmitt-Kopplin. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. Volume: 61 Issue: 22 Pages: 5271-5278. DOI: 10.1021/jf400133w.

36. UV-B mediated metabolic rearrangements in poplar revealed by non-targeted metabolomics. Moritz Kaling, Basem Kanawati, Andrea Ghirardo, Andreas Albert, Jana Winkler, Werner Heller, Csengele Barta, Francesco Lereto, Philippe Schmitt-Kopplin, Joerg-Peter Schnitzler. Plant, Cell & Environment (2014), 38, 5, 892–904.

37. Manganese leads to an increase in markers of oxidative stress as well as to a shift in the ratio of Fe(II)/(III) in rat brain tissue. Katharina Fernsebner, Julia Zorn, Basem Kanawati, Alesia Walker, Bernhard Michalke. Metallomics, (2014), 6, 921-931.

38. Exploring the Arabidopsis sulfur metabolome. Katharina Gläser, Basem Kanawati, Tobias Kubo, Philippe Schmitt-Kopplin, Erwin Grill. The Plant Journal (2014) 77, 31–45.

39. Ultrahigh resolution mass spectrometry-based metabolic characterization reveals cerebellum as a disturbed region in two animal models. Shuhai Lina, Basem Kanawatib, Liangfeng Liu, Michael Witting, Min Li, Jiandong Huang, Philippe Schmitt-Kopplinb, Zongwei Cai. Talanta, Volume 118, (2014), 45–53.

40. Phosphoranide production and decomposition in the gas phase. Basem Kanawati, Karl-Peter Wanczek. International Journal of Mass Spectrometry, (2014), 362, 18–23.

41. Dimer ion formation and intermolecular fragmentation of 1,2-diacylglycerols revealed by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry for more comprehensive lipid analysis. Müller C1, Kanawati B, Rock TM, Forcisi S, Moritz F, Schmitt-Kopplin P. Rapid Communication Mass Spectrometry (2014), 28(15):1735-1744.

42. Arabidopsis enhanced disease susceptibility1 promotes systemic acquired resistance via azelaic acid and its precursor 9-oxo nonanoic acid. Finni Wittek, Thomas Hoffmann, Basem Kanawati, Marlies Bichlmeier, Claudia Knappe, Marion Wenig, Philippe Schmitt-Kopplin, Jane E. Parker, Wilfried Schwab and A. Corina Vlot. Journal of Experimental Botany, (2014), 65, 20, 5919-5931.

43. Folic acid induces salicylic acid-dependent immunity in Arabidopsis and enhances susceptibility to Alternaria brassicicola. MOLECULAR PLANT PATHOLOGY. 16,6,616-622,(2014)DOI:10.1111/mpp.12216. Finni Wittek, Basem Kanawati, Marion Wenig, Thomas Hoffmann, Franz-Oberdorf, Katrin, Wilfried Schwab, Philippe Schmitt-Kopplin, Corina Vlot.

44. Isoprene emission by poplar is not important for the feeding behaviour of poplar leaf beetles. BMC Plant Biology (2015). Anna Müller; Moritz Kaling; Patrick Faubert; Gerrit Gort; Hans M Smid; Joop JA van Loon; Marcel Dicke; Basem Kanawati; Philippe Schmitt-Kopplin; Andrea Polle; Jörg-Peter Schnitzler.

45. Identification of two Arginine Kinase forms of endparasitoid Leptomastix dactylopii venom by bottom up-sequence tag approach. Journal of Mass Spectrometry. (2015), 50, (5), 756–765. Cristiana Labella, Basem Kanawati, Heiko Vogel, Philippe Schmitt-Kopplin, Simona Laurino, Giuliana Bianco, Patrizia Falabella.

46. Diverse Serum Manganese Species affect Brain Metabolites depending on Exposure Conditions. Chemical Research in Toxicology (2015). DOI: 10.1021/acs.chemrestox.5b00104 Katharina Neth, Marianna Lucio, Alesia Walker, Basem Kanawati, Julia Zorn, Philippe Schmitt-Kopplin, and Bernhard Michalke.

47. The in situ gas-phase formation of C-glycoside ion obtained during electrospray ionization tandem mass spectrometry. A unique intramolecular mechanism involving an ion-molecule reaction. Rapid communications in Mass Spectrometry. 29 , 19 , 1717-1732, (2015). Joseph Banoub, Wael L. L. Demian, Paolo Piazzetta, George Sarkis, Basem Kanawati, Dominique Lafont, Nicolas Laurent, Celine Vaillant, Edward Randell, Gianluca Giorgi, Travis Fridgen.

48. Regulatory role of hexosamine biosynthetic pathway on hepatic cancer stem cell marker CD133 under low glucose conditions. Scientific Reports 6,21184, (2016). DOI:10.1038/srep21184. Shu-Hai Lin, Tengfei Liu, Xiaoyan Ming, Zhi Tang, Li Fu, Philippe Schmitt-Kopplin, Basem Kanawati, Xin-Yuan Guan, Zongwei Cai

49. Proposed Guidelines for Solid Phase Extraction of Suwannee River Dissolved Organic Matter. Anal. Chem., (2016), 88 (13), pp 6680–6688. DOI: 10.1021/acs.analchem.5b04501. Yan Li, Mourad Harir, Marianna Lucio, Basem Kanawati, Kirill Smirnov, Ruth Flerus, Boris P. Koch, Philippe Schmitt-Kopplin, and Norbert Hertkorn.

50. Metabolic Fingerprint of PS3-Induced Resistance of Grapevine Leaves against Plasmopara viticola Revealed Differences in Elicitor-Triggered Defenses. Frontiers in Plant Science 8 (82) (2017). Marielle Adrian, Marianna Lucio, Chloé Roullier-Gall, Marie-Claire Héloir, Sophie Trouvelot, Xavier Daire, Basem Kanawati, Christelle Lemaître-Guillier, Benoît Poinssot, Régis Gougeon , Philippe Schmitt-Kopplin.

51. Previously unknown class of metalorganic compounds revealed in meteorites. Proceedings of the National Academy of Sciences PNAS.(2017). DOI: 10.1073/pnas.1616019114. Alexander Ruf, Basem Kanawati, Norbert Hertkorn, Qing-Zhu Yin, Franco Moritz, Mourad Harir, Marianna Lucio, Bernhard Michalke, Joshua Wimpenny, Svetlana Shilobreev, Basil Bronsky, Vladimir Saraykin, Zelimir Gabelica, Régis D. Gougeon, Eric Quirico, Stefan Ralew, Tomasz Jakubowski, Henning Haack, Michael Gonsior, Peter Jenniskens, Nancy W. Hinman, Philippe Schmitt-Kopplin.

52. How representative are dissolved organic matter (DOM) extracts? A comprehensive study of sorbent selectivity for DOM isolation. Water Research, (2017),116, 316–323. Yan Li, Mourad Harir, Jenny Uhl, Basem Kanawati, Marianna Lucio, Kirill S. Smirnov, Boris P. Koch, Philippe Schmitt-Kopplin, Norbert Hertkorn.







 
Address:

Dr. Basem Kanawati
Helmholtz Center Munich (GmbH)
Research Center for Environmental Health
Research Unit Analytical BioGeoChemistry
Department of Environmental Sciences
Ingolstädter Landstr. 1
85764 Neuherberg, Germany
Tel: +49-(0)89-3187-2412
Email: Kanawati.B@gmail.com